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| Dosing and Titration |
| Flexible Once-Daily Dosing |
| Provide appropriate patients with a 2-week sample kit. |
Titration Schedule With Requip
After completion of the Sample Kit, as needed by the patient, titrate Requip in weekly increments of 0.5 mg up to a total dose of 3 mg/day, and then by 1 mg weekly to a maximum total dose of 4 mg/day.
The safety and effectiveness of Requip at >4 mg/day in patients with RLS have not been established.
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Help Your Patients Get Off to a Good Start With Requip
- Instruct patients to take their medication every day, 1 to 3 hours before bedtime, even if symptoms are not present
- Continue dose titration as needed up to 4 mg/day based on adequate clinical response and tolerability
- If a dose is missed, patients should be advised not to double their next dose
- If a significant interruption in therapy with Requip has occurred, retitration of therapy may be warranted
- Occurrence of nausea in clinical trials was generally mild to moderate in intensity; taking Requip with food may reduce the occurrence of nausea*
- When increasing the dosage of Requip, caution patients about the potential for feeling faint, dizzy, or nauseated when standing from a sitting position
*This has not been established in controlled clinical trials.
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Requip is indicated for patients with moderate-to-severe primary RLS.
Requip has been associated with sedating effects, including somnolence, and the possibility of falling asleep while engaged in activities of daily living, including operation of a motor vehicle. Syncope or symptomatic hypotension may occur, particularly during initial treatment or dose titration. Impulse control symptoms, including pathological gambling and hypersexuality, have been reported in patients treated with dopaminergic agents, including ropinirole.
For More Safety Information about Requip, click here.
Complete Prescribing Information for Requip® (ropinirole HCl) Tablets
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Dosing and Titration
